Generic Name: Domperidone Maleate 10mg
Company Name: Beximco Pharmaceuticals Ltd.
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Indications
A prescription drug called Deflux Meltab Dispersible is used to treat nausea, vomiting, and indigestion. It enhances food movement in the stomach, which helps with digestion, and blocks the brain chemical that causes nausea or vomiting. Before meals, take Deflux Meltab Dispersible in the dosage and for the recommended amount of time.
Pharmacology
Domperidone is a dopamine antagonist that mainly blocks dopamine receptors located in the chemoreceptor activation zone (CTZ) and stomach. Its gastrointestinal motility is based on its blocking effect on dopamine receptors that affect gastrointestinal motility. Due to its weak permeability to the blood-brain barrier, domperidone has almost no effect on dopamine receptors in the brain, thus eliminating mental and neurological side effects. Domperidone restores the normal movement and tension of the upper gastrointestinal tract, promotes gastric emptying, improves gastric antrum and duodenal peristalsis, and regulates pyloric contraction. Domperidone also increases esophageal motility and reduces esophageal sphincter pressure, thereby preventing the reflux of stomach contents.
Dosage & Administration
If necessary, take Deflux before bedtime and between 15 and 30 minutes before meals. The usual dosages for oral administration of those who use domperidone include:
In acute and subacute situations (mainly acute nausea and vomiting):
Indigestion symptoms:
Rectal suppositories:
Interaction
Deflux can reduce the risk of bromocriptine-causing hypoprolactin. The effect of domperidone on GI function can be antagonized by antimuscarinic drugs and opioid analgesics. Caution should be exercised when domperidone is administered in combination with MAO (monoamine oxidase) inhibitors.
Contraindications
Deflux is contraindicated in patients and newborns who are known to be allergic to this drug. Domperidone should not be used when gastrointestinal irritation could be dangerous, ie gastrointestinal bleeding, mechanical obstruction, or perforation. Prolactin-releasing pituitary tumors (prolactinomas) are also contraindicated.
Side Effects
Domperidone can cause hyperprolactinemia (1.3%). This can cause galactorrhea, breast enlargement, pain, and decreased libido. Dry mouth (1%), thirst, headache (1.2%), nervousness, drowsiness (0.4%), diarrhea (0.2%), rash, and itching ( 0.1%). In clinical studies, 0.05% of patients had extrapyramidal reactions.
Pregnancy & Lactation
The safety of domperidone has not been proven, so its use during pregnancy is not recommended. Animal studies have not shown teratogenic effects on the fetus. Domperidone can cause galactorrhea and improve postpartum lactation. It is secreted in breast milk, but the amount is very small and not enough to be considered harmful.
Precautions & Warnings
The safety of Deflux has not been proven, so its use during pregnancy is not recommended. Animal studies have not shown teratogenic effects on the fetus. Domperidone can cause galactorrhea and improve postpartum lactation. It is secreted in breast milk, but the amount is very small and not enough to be considered harmful.
Storage Conditions
Store below 30 ° C protected from light and moisture. Keep out of the reach of children.
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